Two sample MR report

Telomere_length against BA-exvivo rh area BA2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0090533	0.1084802	0.9342793
Weighted median	23	-0.0058732	0.0616897	0.9241521
Inverse variance weighted	23	-0.0263828	0.0414462	0.5244146
Simple mode	23	0.0267230	0.1155420	0.8192317
Weighted mode	23	0.0051046	0.0809493	0.9502890

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.00833	21	0.2468033
Inverse variance weighted	25.04420	22	0.2949656

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001064	0.0061311	0.8638837

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007729	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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