Two sample MR report

Telomere_length against BA-exvivo rh area BA1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0269086	0.1217201	0.8271739
Weighted median	23	0.0384468	0.0623388	0.5374059
Inverse variance weighted	23	-0.0455252	0.0465019	0.3275816
Simple mode	23	0.0305838	0.1326255	0.8197541
Weighted mode	23	0.0749706	0.0854017	0.3895073

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.48592	21	0.0659425
Inverse variance weighted	31.52732	22	0.0858194

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011431	0.0068794	0.8696222

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000997	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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