Two sample MR report

Telomere_length against BA-exvivo lh volume perirhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0351331	0.1124054	0.7576995
Weighted median	23	-0.0620315	0.0570092	0.2765519
Inverse variance weighted	23	-0.0839146	0.0431418	0.0517641
Simple mode	23	-0.0917726	0.0987849	0.3629635
Weighted mode	23	-0.0618529	0.0552951	0.2753787

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.85075	21	0.1758482
Inverse variance weighted	27.13496	22	0.2061454

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029952	0.0063529	0.6421692

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009637	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8