Two sample MR report

Telomere_length against BA-exvivo lh volume entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0980678	0.1184365	0.4169707
Weighted median	23	-0.0748888	0.0558267	0.1797741
Inverse variance weighted	23	-0.1002733	0.0452183	0.0265864
Simple mode	23	-0.0517985	0.0877502	0.5610078
Weighted mode	23	-0.0784968	0.0613328	0.2139306

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.80976	21	0.0958781
Inverse variance weighted	29.81034	22	0.1231476

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001354	0.0066937	0.9840504

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011052	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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