Two sample MR report

Telomere_length against BA-exvivo lh volume V2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1616051	0.1456607	0.2797746
Weighted median	23	-0.0165132	0.0600555	0.7833427
Inverse variance weighted	23	-0.0412794	0.0566680	0.4663425
Simple mode	23	-0.0429278	0.1110753	0.7028580
Weighted mode	23	-0.0056545	0.0718828	0.9380118

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.08954	21	0.0016857
Inverse variance weighted	46.81878	22	0.0015496

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007388	0.0082324	0.3796657

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014528	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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