Two sample MR report

Telomere_length against BA-exvivo lh volume V1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1576126	0.1451229	0.2897612
Weighted median	23	-0.1363325	0.0643349	0.0340815
Inverse variance weighted	23	-0.0473489	0.0562981	0.4003264
Simple mode	23	-0.2085470	0.1293498	0.1211574
Weighted mode	23	-0.2085470	0.0960993	0.0410700

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.75804	21	0.0018631
Inverse variance weighted	46.21019	22	0.0018580

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067702	0.008202	0.418407

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014452	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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