Two sample MR report

Telomere_length against BA-exvivo lh volume MT

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0011786	0.1222356	0.9923979
Weighted median	23	-0.0308393	0.0644916	0.6325147
Inverse variance weighted	23	0.0347233	0.0467815	0.4579389
Simple mode	23	0.1140319	0.1288047	0.3855646
Weighted mode	23	-0.0439755	0.0889568	0.6259616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.75355	21	0.0619989
Inverse variance weighted	31.90750	22	0.0789867

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022044	0.0069085	0.752816

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009911	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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