Two sample MR report

Telomere_length against BA-exvivo lh volume BA6

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1964604	0.1176697	0.1098406
Weighted median	23	-0.1394427	0.0564852	0.0135621
Inverse variance weighted	23	-0.1192985	0.0454648	0.0086910
Simple mode	23	-0.0990873	0.0969805	0.3180163
Weighted mode	23	-0.1410171	0.0638447	0.0379110

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.42568	21	0.1041509
Inverse variance weighted	30.13681	22	0.1151768

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047377	0.0066504	0.4840605

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011989	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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