Two sample MR report

Telomere_length against BA-exvivo lh volume BA4p

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2054456	0.1355728	0.1445821
Weighted median	23	-0.0285308	0.0645798	0.6586396
Inverse variance weighted	23	-0.0751759	0.0530858	0.1567405
Simple mode	23	-0.0425385	0.1239636	0.7347407
Weighted mode	23	-0.0425385	0.0792997	0.5970467

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.06069	21	0.0096528
Inverse variance weighted	41.08757	22	0.0080456

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079985	0.0076623	0.3084068

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013584	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8