Two sample MR report

Telomere_length against BA-exvivo lh volume BA4a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2335766	0.1155918	0.0562452
Weighted median	23	-0.1435886	0.0637359	0.0242675
Inverse variance weighted	23	-0.1041778	0.0456594	0.0225113
Simple mode	23	-0.0020515	0.1289797	0.9874531
Weighted mode	23	-0.1869721	0.0898760	0.0493499

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.39586	21	0.1292772
Inverse variance weighted	30.39576	22	0.1091584

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079451	0.006533	0.2374231

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001139	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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