Two sample MR report

Telomere_length against BA-exvivo lh volume BA45

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2168491	0.0994057	0.0406597
Weighted median	23	-0.0554047	0.0555624	0.3186866
Inverse variance weighted	23	-0.0567446	0.0388453	0.1440747
Simple mode	23	0.0654356	0.1035009	0.5337576
Weighted mode	23	-0.1229575	0.0723440	0.1032996

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.37345	21	0.7483147
Inverse variance weighted	19.43506	22	0.6183317

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0098305	0.0056183	0.0947625

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006536	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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