Two sample MR report

Telomere_length against BA-exvivo lh volume BA44

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2324333	0.1024615	0.0339653
Weighted median	23	-0.1081415	0.0601125	0.0720209
Inverse variance weighted	23	-0.0611382	0.0420792	0.1462431
Simple mode	23	-0.1153636	0.1047909	0.2828433
Weighted mode	23	-0.1420788	0.0806394	0.0919773

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.31092	21	0.3817867
Inverse variance weighted	25.81547	22	0.2596890

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0105176	0.0057909	0.0836417

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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