Two sample MR report

Telomere_length against BA-exvivo lh volume BA3b

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2279914	0.1241674	0.0805334
Weighted median	23	-0.1327340	0.0541371	0.0142139
Inverse variance weighted	23	-0.1390760	0.0480842	0.0038238
Simple mode	23	-0.1077722	0.0857610	0.2220573
Weighted mode	23	-0.1282347	0.0625595	0.0524898

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.76577	21	0.0488797
Inverse variance weighted	33.71006	22	0.0525596

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054594	0.0070177	0.4452752

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014098	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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