Two sample MR report

Telomere_length against BA-exvivo lh volume BA3a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1709691	0.1338266	0.2153545
Weighted median	23	-0.0395583	0.0604282	0.5127035
Inverse variance weighted	23	-0.0519036	0.0522177	0.3202295
Simple mode	23	-0.1083142	0.1106541	0.3382945
Weighted mode	23	-0.0502527	0.0708003	0.4852959

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.06090	21	0.0126784
Inverse variance weighted	39.75412	22	0.0115492

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073106	0.0075636	0.3447677

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012587	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8