Two sample MR report

Telomere_length against BA-exvivo lh volume BA2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0716814	0.0994065	0.4788033
Weighted median	23	-0.0413731	0.0568158	0.4664934
Inverse variance weighted	23	-0.0339901	0.0388456	0.3815713
Simple mode	23	0.0695873	0.1029550	0.5061480
Weighted mode	23	0.0241914	0.0824905	0.7720699

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.08848	21	0.8184861
Inverse variance weighted	15.25816	22	0.8509230

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023143	0.0056183	0.6845744

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004856	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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