Two sample MR report

Telomere_length against BA-exvivo lh volume BA1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3081635	0.1158267	0.0146324
Weighted median	23	-0.1389855	0.0597370	0.0199853
Inverse variance weighted	23	-0.1116723	0.0476639	0.0191340
Simple mode	23	-0.2196863	0.1072648	0.0526728
Weighted mode	23	-0.1567406	0.0703951	0.0365287

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.51160	21	0.1262294
Inverse variance weighted	33.12305	22	0.0601638

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0120646	0.0065463	0.079496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012541	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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