Two sample MR report

Telomere_length against BA-exvivo lh thickness perirhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0350440	0.1093502	0.7517755
Weighted median	23	-0.0319306	0.0529333	0.5463599
Inverse variance weighted	23	-0.0706042	0.0418726	0.0917634
Simple mode	23	-0.0586878	0.0956935	0.5459735
Weighted mode	23	-0.0227722	0.0594598	0.7054060

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.41085	21	0.2298086
Inverse variance weighted	25.56188	22	0.2709671

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021834	0.0061802	0.7273952

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008746	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8