Two sample MR report

Telomere_length against BA-exvivo lh thickness entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1300565	0.1061155	0.2339126
Weighted median	23	-0.0366897	0.0543906	0.4999555
Inverse variance weighted	23	-0.0438380	0.0412584	0.2879990
Simple mode	23	0.0165352	0.0922756	0.8594259
Weighted mode	23	-0.0361284	0.0591205	0.5473977

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.92943	21	0.2964902
Inverse variance weighted	24.81725	22	0.3058938

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052938	0.0059974	0.3874009

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007905	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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