Two sample MR report

Telomere_length against BA-exvivo lh thickness V2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3494184	0.1107244	0.0047681
Weighted median	23	-0.1188207	0.0578165	0.0398659
Inverse variance weighted	23	-0.1119531	0.0474239	0.0182411
Simple mode	23	-0.0905937	0.1059385	0.4016837
Weighted mode	23	-0.1476775	0.0644788	0.0319551

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.05493	21	0.2043622
Inverse variance weighted	32.79013	22	0.0648876

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0145805	0.006258	0.0298663

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012453	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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