Two sample MR report

Telomere_length against BA-exvivo lh thickness V1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2709297	0.0994060	0.0126721
Weighted median	23	-0.1348243	0.0577854	0.0196382
Inverse variance weighted	23	-0.1012914	0.0405871	0.0125726
Simple mode	23	-0.2209423	0.0965944	0.0321585
Weighted mode	23	-0.1461600	0.0718585	0.0541844

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.57988	21	0.4848435
Inverse variance weighted	24.01695	22	0.3463417

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0104158	0.0056182	0.0778491

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009338	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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