Two sample MR report

Telomere_length against BA-exvivo lh thickness MT

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0677608	0.1246405	0.5924076
Weighted median	23	-0.0790323	0.0600135	0.1878697
Inverse variance weighted	23	-0.0398868	0.0476533	0.4025800
Simple mode	23	-0.0787243	0.1193716	0.5164264
Weighted mode	23	-0.0903932	0.0768519	0.2520861

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.01455	21	0.0460560
Inverse variance weighted	33.10735	22	0.0603797

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017115	0.0070444	0.8103992

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010351	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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