Two sample MR report

Telomere_length against BA-exvivo lh thickness BA6

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1947726	0.1149715	0.1050287
Weighted median	23	-0.0991490	0.0561093	0.0772168
Inverse variance weighted	23	-0.1024243	0.0446843	0.0218955
Simple mode	23	-0.0836364	0.0881301	0.3529243
Weighted mode	23	-0.0799124	0.0728622	0.2846069

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.09226	21	0.1375541
Inverse variance weighted	29.11088	22	0.1417223

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056702	0.006498	0.3927419

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010927	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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