Two sample MR report

Telomere_length against BA-exvivo lh thickness BA4p

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1713332	0.1184403	0.1627771
Weighted median	23	-0.0768624	0.0638344	0.2285545
Inverse variance weighted	23	-0.0729471	0.0460877	0.1134695
Simple mode	23	-0.0652028	0.1168902	0.5826050
Weighted mode	23	-0.0846864	0.0761572	0.2781448

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.81163	21	0.0958392
Inverse variance weighted	30.96774	22	0.0967776

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060409	0.006694	0.3770601

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010452	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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