Two sample MR report

Telomere_length against BA-exvivo lh thickness BA4a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1878833	0.1058187	0.0903073
Weighted median	23	-0.0854077	0.0585994	0.1449826
Inverse variance weighted	23	-0.0610612	0.0419997	0.1459889
Simple mode	23	-0.1383792	0.0959922	0.1635085
Weighted mode	23	-0.1294623	0.0804733	0.1219259

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.79677	21	0.3030097
Inverse variance weighted	25.71778	22	0.2639963

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077869	0.0059807	0.2070127

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008542	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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