Two sample MR report

Telomere_length against BA-exvivo lh thickness BA45

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1968752	0.0994068	0.0608979
Weighted median	23	-0.0689441	0.0576217	0.2315029
Inverse variance weighted	23	-0.0254391	0.0388457	0.5125482
Simple mode	23	-0.0665147	0.1031980	0.5258926
Weighted mode	23	-0.0969688	0.0758054	0.2141616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.28114	21	0.8085853
Inverse variance weighted	18.79139	22	0.6581727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0105262	0.0056183	0.074975

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005824	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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