Two sample MR report

Telomere_length against BA-exvivo lh thickness BA44

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1212510	0.0994077	0.2360878
Weighted median	23	-0.0348195	0.0558206	0.5327759
Inverse variance weighted	23	-0.0035057	0.0388460	0.9280917
Simple mode	23	-0.0800968	0.1010418	0.4364125
Weighted mode	23	-0.0108753	0.0678083	0.8740433

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.88839	21	0.7178494
Inverse variance weighted	18.54420	22	0.6732792

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0072295	0.0056183	0.2121736

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005622	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

Funnel plot

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Leave-one-out sensitivity analysis

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