Two sample MR report

Telomere_length against BA-exvivo lh thickness BA3b

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2429126	0.0994060	0.0234571
Weighted median	23	-0.1608365	0.0517959	0.0019015
Inverse variance weighted	23	-0.1459314	0.0388455	0.0001722
Simple mode	23	-0.1727210	0.0789889	0.0396902
Weighted mode	23	-0.1567979	0.0618325	0.0188295

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.52401	21	0.7395246
Inverse variance weighted	17.64736	22	0.7266795

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059547	0.0056182	0.3012367

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009624	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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