Two sample MR report

Telomere_length against BA-exvivo lh thickness BA3a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1970037	0.0994065	0.0607424
Weighted median	23	-0.0691096	0.0554895	0.2129655
Inverse variance weighted	23	-0.0902876	0.0388458	0.0201117
Simple mode	23	-0.1167664	0.0941234	0.2278336
Weighted mode	23	-0.0750563	0.0720468	0.3088316

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.56961	21	0.8439121
Inverse variance weighted	15.92979	22	0.8193548

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065524	0.0056183	0.2565809

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006464	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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