Two sample MR report

Telomere_length against BA-exvivo lh thickness BA2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1768559	0.0994069	0.0897013
Weighted median	23	-0.0881328	0.0573198	0.1241556
Inverse variance weighted	23	-0.0378117	0.0397113	0.3410143
Simple mode	23	-0.1445725	0.0947513	0.1413060
Weighted mode	23	-0.0935085	0.0637682	0.1566936

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.68229	21	0.4784874
Inverse variance weighted	22.99137	22	0.4022169

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085373	0.0056183	0.1435338

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007254	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8