Two sample MR report

Telomere_length against BA-exvivo lh thickness BA1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3027087	0.0994054	0.0061512
Weighted median	23	-0.1714551	0.0567170	0.0025029
Inverse variance weighted	23	-0.1199253	0.0411374	0.0035542
Simple mode	23	-0.1726740	0.0873833	0.0608214
Weighted mode	23	-0.1726740	0.0602103	0.0089403

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.68270	21	0.4784620
Inverse variance weighted	24.67312	22	0.3129603

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.011223	0.0056182	0.0588782

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010365	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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