Two sample MR report

Telomere_length against BA-exvivo lh area perirhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0396148	0.1333012	0.7692469
Weighted median	23	-0.0887201	0.0561088	0.1138288
Inverse variance weighted	23	-0.0982260	0.0511690	0.0549036
Simple mode	23	-0.0945255	0.0831969	0.2681127
Weighted mode	23	-0.1056898	0.0547589	0.0665879

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.76273	21	0.0137385
Inverse variance weighted	38.17303	22	0.0175194

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035987	0.0075338	0.6378183

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013504	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8