Two sample MR report

Telomere_length against BA-exvivo lh area entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0195372	0.1449536	0.8940673
Weighted median	23	-0.0943815	0.0569322	0.0973606
Inverse variance weighted	23	-0.1127792	0.0559817	0.0439496
Simple mode	23	-0.0651517	0.0816462	0.4334144
Weighted mode	23	-0.0971667	0.0599661	0.1194019

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.65384	21	0.0019225
Inverse variance weighted	45.69225	22	0.0021658

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005725	0.0081924	0.4923321

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016397	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8