Two sample MR report

Telomere_length against BA-exvivo lh area V2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0595444	0.1370978	0.6684854
Weighted median	23	0.1057511	0.0622462	0.0893348
Inverse variance weighted	23	0.0396056	0.0523742	0.4495265
Simple mode	23	-0.1285119	0.1349164	0.3511773
Weighted mode	23	0.1647836	0.0864436	0.0697641

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.94553	21	0.007551
Inverse variance weighted	39.99302	22	0.010832

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012243	0.0077485	0.8759675

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012434	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8