Two sample MR report

Telomere_length against BA-exvivo lh area V1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0060100	0.1294841	0.9634182
Weighted median	23	-0.0419592	0.0629135	0.5048138
Inverse variance weighted	23	0.0119994	0.0494630	0.8083196
Simple mode	23	-0.0768491	0.1212925	0.5328840
Weighted mode	23	-0.0271543	0.1002484	0.7890158

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.63206	21	0.0240386
Inverse variance weighted	35.67080	22	0.0329249

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011058	0.0073182	0.8813384

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010837	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8