Two sample MR report

Telomere_length against BA-exvivo lh area MT

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0578869	0.1058433	0.5902049
Weighted median	23	0.0381113	0.0619633	0.5385133
Inverse variance weighted	23	0.0536231	0.0404119	0.1845375
Simple mode	23	0.0431978	0.1191347	0.7203664
Weighted mode	23	-0.0137554	0.0974442	0.8890271

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.80757	21	0.3024755
Inverse variance weighted	23.80974	22	0.3572810

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002618	0.0059821	0.9655059

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007792	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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