Two sample MR report

Telomere_length against BA-exvivo lh area BA6

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0465386	0.1041661	0.6596121
Weighted median	23	-0.0161114	0.0560358	0.7737138
Inverse variance weighted	23	-0.0419781	0.0397715	0.2912057
Simple mode	23	-0.0185178	0.0911585	0.8408941
Weighted mode	23	-0.0216812	0.0642488	0.7389707

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.05844	21	0.3408706
Inverse variance weighted	23.06092	22	0.3982965

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00028	0.0058872	0.9625135

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007342	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8