Two sample MR report

Telomere_length against BA-exvivo lh area BA4p

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1148340	0.0994079	0.2609924
Weighted median	23	-0.0417135	0.0540575	0.4403209
Inverse variance weighted	23	-0.0096974	0.0388459	0.8028670
Simple mode	23	-0.0325444	0.0857112	0.7078103
Weighted mode	23	-0.0424319	0.0652687	0.5223521

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.95722	21	0.7720502
Inverse variance weighted	17.27739	22	0.7478698

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064554	0.0056183	0.2634804

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005254	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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