Two sample MR report

Telomere_length against BA-exvivo lh area BA4a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0669597	0.0994076	0.5079204
Weighted median	23	-0.0360992	0.0581830	0.5349662
Inverse variance weighted	23	-0.0349725	0.0388458	0.3679657
Simple mode	23	0.0184719	0.1038336	0.8604298
Weighted mode	23	-0.0191375	0.0706605	0.7890405

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.27347	21	0.5676019
Inverse variance weighted	19.39568	22	0.6207849

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001964	0.0056183	0.7301399

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006123	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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