Two sample MR report

Telomere_length against BA-exvivo lh area BA45

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1306624	0.1075006	0.2376802
Weighted median	23	-0.0841823	0.0592368	0.1552832
Inverse variance weighted	23	-0.0389839	0.0418730	0.3518530
Simple mode	23	-0.0685545	0.1259852	0.5918128
Weighted mode	23	-0.0933501	0.0865359	0.2923879

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.55929	21	0.2667555
Inverse variance weighted	25.56316	22	0.2709095

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056291	0.0060758	0.364719

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008051	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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