Two sample MR report

Telomere_length against BA-exvivo lh area BA44

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1400988	0.1097789	0.2158225
Weighted median	23	-0.1149888	0.0573968	0.0451344
Inverse variance weighted	23	-0.0609195	0.0425208	0.1519435
Simple mode	23	-0.1728060	0.1053918	0.1152995
Weighted mode	23	-0.1489986	0.0795641	0.0744623

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.61130	21	0.2216595
Inverse variance weighted	26.36009	22	0.2365431

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048616	0.0062045	0.4420435

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008733	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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