Two sample MR report

Telomere_length against BA-exvivo lh area BA3b

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0986416	0.1200482	0.4204883
Weighted median	23	-0.0132981	0.0613716	0.8284559
Inverse variance weighted	23	-0.0126500	0.0464893	0.7855417
Simple mode	23	-0.0428150	0.1153186	0.7139836
Weighted mode	23	-0.0073778	0.0754774	0.9230171

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.62649	21	0.0801028
Inverse variance weighted	31.50966	22	0.0861485

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052799	0.0067849	0.4451392

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000958	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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