Two sample MR report

Telomere_length against BA-exvivo lh area BA3a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1082953	0.1366287	0.4368599
Weighted median	23	0.0070796	0.0602210	0.9064157
Inverse variance weighted	23	-0.0016007	0.0530494	0.9759287
Simple mode	23	0.0348709	0.1022104	0.7362146
Weighted mode	23	0.0103350	0.0797787	0.8981026

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.67116	21	0.0081518
Inverse variance weighted	41.03079	22	0.0081718

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065511	0.007722	0.4058015

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012432	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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