Two sample MR report

Telomere_length against BA-exvivo lh area BA2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0530521	0.0994072	0.5991639
Weighted median	23	0.0358056	0.0534293	0.5027627
Inverse variance weighted	23	0.0099068	0.0388461	0.7987031
Simple mode	23	0.0482808	0.0829896	0.5666366
Weighted mode	23	0.0502326	0.0680302	0.4680833

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.88092	21	0.9427769
Inverse variance weighted	12.10325	22	0.9552100

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026491	0.0056183	0.6421322

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003687	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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