Two sample MR report

Telomere_length against BA-exvivo lh area BA1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0257741	0.0994078	0.7979470
Weighted median	23	-0.0113053	0.0567132	0.8419954
Inverse variance weighted	23	0.0023265	0.0388460	0.9522429
Simple mode	23	-0.0000299	0.0918714	0.9997429
Weighted mode	23	-0.0149490	0.0622893	0.8125581

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.79174	21	0.5344852
Inverse variance weighted	19.88604	22	0.5901678

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017254	0.0056183	0.7617933

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006027	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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