Two sample MR report

Telomere_length against AmygNuclei rh volume Whole-amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1371522	0.0994068	0.1821920
Weighted median	23	0.0203968	0.0513475	0.6911978
Inverse variance weighted	23	-0.0027305	0.0388456	0.9439614
Simple mode	23	0.0224563	0.0899389	0.8051480
Weighted mode	23	0.0354408	0.0620270	0.5735351

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.45141	21	0.8919916
Inverse variance weighted	15.78843	22	0.8262456

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0085887	0.0056182	0.1412555

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004786	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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