Two sample MR report

Telomere_length against AmygNuclei rh volume Paralaminar-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1348371	0.0994062	0.1893691
Weighted median	23	0.0555468	0.0543160	0.3064691
Inverse variance weighted	23	0.0400873	0.0388453	0.3020845
Simple mode	23	0.0110296	0.0875647	0.9009085
Weighted mode	23	0.0605906	0.0628258	0.3453163

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.60832	21	0.6736377
Inverse variance weighted	18.68057	22	0.6649617

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058176	0.0056182	0.3122167

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005984	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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