Two sample MR report

Telomere_length against AmygNuclei rh volume Medial-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1216077	0.1026490	0.2493734
Weighted median	23	0.0601836	0.0612965	0.3261770
Inverse variance weighted	23	0.0661465	0.0395104	0.0941004
Simple mode	23	0.0353750	0.1009765	0.7294237
Weighted mode	23	0.0353750	0.0746705	0.6403472

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.39271	21	0.3771906
Inverse variance weighted	22.76010	22	0.4153805

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034053	0.0058015	0.5634809

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007775	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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