Two sample MR report

Telomere_length against AmygNuclei rh volume Corticoamygdaloid-transitio

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0955377	0.1102116	0.3958175
Weighted median	23	-0.0067265	0.0605253	0.9115094
Inverse variance weighted	23	-0.0518993	0.0441430	0.2397122
Simple mode	23	0.0764818	0.1047706	0.4730966
Weighted mode	23	0.0300030	0.0691288	0.6685038

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.81386	21	0.2136358
Inverse variance weighted	28.41017	22	0.1624830

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0090525	0.0062289	0.1609159

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000915	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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