Two sample MR report

Telomere_length against AmygNuclei rh volume Cortical-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1461902	0.1081299	0.1907623
Weighted median	23	-0.0006407	0.0567300	0.9909894
Inverse variance weighted	23	0.0177929	0.0428874	0.6782339
Simple mode	23	0.1538161	0.1113698	0.1811082
Weighted mode	23	0.0656214	0.0707388	0.3636515

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.84796	21	0.2538093
Inverse variance weighted	26.81701	22	0.2182593

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0078836	0.0061113	0.211073

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000819	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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