Two sample MR report

Telomere_length against AmygNuclei rh volume Central-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0036698	0.0994058	0.9708994
Weighted median	23	-0.0514711	0.0575813	0.3713831
Inverse variance weighted	23	-0.0419917	0.0388452	0.2796968
Simple mode	23	-0.0426353	0.0968188	0.6639715
Weighted mode	23	-0.0590413	0.0816551	0.4772623

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.05339	21	0.8202635
Inverse variance weighted	15.30241	22	0.8489363

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028036	0.0056182	0.6229496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004991	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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